Noncancerous Conditions of the Prostate
Having a family history of prostate cancer increases your risk of developing the disease, and doctors may perform genetic testing as part of their evaluation. There is no known cure for the disease, and treatment includes active surveillance and watchful waiting. There are also some noncancerous conditions of the prostate, and a biopsy can help determine if you have these, as well.
Hormone therapy does not cure prostate cancer
During hormone therapy, you may experience feelings of fatigue, memory loss, and hot flashes. These effects are related to low testosterone levels in your body. However, they usually go away after a few weeks.
Before you start hormone therapy, your doctor will test you to see if you have prostate cancer. Your doctor will then prescribe medicines that keep your prostate cancer cells from getting the testosterone they need to grow.
For advanced prostate cancer, your doctor might recommend radiation and chemotherapy. These treatments destroy cancer cells. They also may stop them from spreading. These treatments are often combined with hormone therapy.
Another type of treatment for advanced prostate cancer is surgery. Surgical techniques include TURP or transurethral resection of the prostate. This surgery is performed under general anesthesia. This procedure removes pieces of the prostate gland and relieves pressure on the tube carrying urine from the bladder out of the penis.
Other treatments are used to slow the growth of cancer and improve the quality of life for some patients. These treatments are not approved for most patients with prostate cancer.
Some patients with prostate cancer may be offered surgery to remove the entire gland. Some hospitals are offering new minimally invasive treatments, such as cryotherapy and high-intensity focused ultrasound.
Other types of hormone therapy include neoadjuvant therapy and adjuvant therapy. Neoadjuvant therapy is sometimes used in conjunction with radiation therapy to shrink the tumor. This helps make the main treatment more effective.
Treatment involves PSA tests and biopsies
During the process of treating prostate cancer, PSA tests and biopsies may be performed. The results of the tests help to determine the stage of the disease and the treatment that will be best suited for the individual. These tests can also help to detect if cancer has spread.
A PSA test is a blood test that measures the level of prostate-specific antigen (PSA), a protein that is produced by prostate cells. A high PSA level indicates that the prostate is more likely to be affected by cancer. For most men in their 50s, a PSA level of 2.5 is considered normal.
The Gleason grading system helps doctors determine the rate of cancer growth and spread. A grade of three indicates a low risk, while a grade of seven indicates middle-range cancer. A grade of eight is considered to be high-risk cancer.
A bone scan can be performed to find out if cancer has spread to the bones. If the cancer is localized, surgery or radiation therapy will be used to destroy it. However, if cancer has spread to other parts of the body, chemotherapy or hormone therapy will be used.
During a biopsy, a small tissue sample is taken from the prostate and sent to the lab for examination. The sample is then evaluated by a pathologist. The results are assigned a “score” based on how aggressive the prostate cancer is.
Active surveillance and watchful waiting
Regardless of the stage of prostate cancer, a man should talk to his primary care physician about options. Active surveillance and watchful waiting for prostate cancer are two approaches that may help. The benefits of one over the other vary depending on the situation.
Active surveillance involves regular doctor visits. These visits include a PSA blood test, which measures the level of prostate-specific antigen in the blood. These tests are usually repeated every six months. The reason for the repetition is to keep an eye on the growth of the tumor. A biopsy is typically performed every one to three years.
The watchful waiting option is less intensive and may be better suited for older men with limited life expectancy. During watchful waiting, patients do not undergo repeat biopsies or undergo invasive testing. Symptoms such as frequent urination, a burning sensation while urinating, and pain during urination are common.
The benefits of watchful waiting are more related to the management of symptoms than the cure. During the wait, the patient is asked to report any changes to the care team. This is to ensure that the patient is comfortable. Some symptoms that may be caused by the cancer are a burning or dull ache in the lower pelvis or back, painful urination, and difficulty stopping urination.
On the other hand, active surveillance is a more aggressive form of prostate cancer monitoring. It may involve deferred therapy such as surgery or radiation therapy. Often, imaging tests such as magnetic resonance imaging (MRI) and digital rectal exams (DRE) are performed.
Genetic testing may be the first step doctors take when diagnosing prostate cancer
Among men, prostate cancer is the second most common cancer. One in nine men will be diagnosed with prostate cancer at some point during his lifetime. However, the risk of having cancer that progresses to a life-threatening stage is relatively low.
In recent years, advances in diagnosis and treatment have dramatically improved the five-year survival rate for men with prostate cancer. This is a good thing.
When a man is diagnosed with prostate cancer, he is faced with a number of treatment options. The decision on which treatment is right for him depends on his age, health, and other factors. In addition, he may want to consider genomic testing to get a more in-depth look at the disease.
A genomic test will analyze the DNA of cancer cells. This can give doctors more information about a patient’s risk of developing cancer and how aggressive it is. It may also tell them if a person has inherited a genetic mutation that increases his chances of getting the disease.
A needle biopsy will collect a sample of tissue and send it to a laboratory for analysis. The sample will be examined by a pathologist. The result will be a Gleason score. A higher score means the cancer is more aggressive.
A bone scan is usually ordered if the tumor appears to be spreading to the bone. This scan uses radioactive material to determine where the disease is located. It is also used to check for lymph nodes that are enlarged.
Spread to bones and lymph nodes
Among the major types of prostate cancer, metastatic disease is characterized by the spread of cancer cells to lymph nodes, other organs, and bones. This progression is associated with high morbidity and mortality, as well as a poor prognosis.
This type of cancer can be treated by biological therapy, which uses the body’s immune system to attack the cancer cells. The treatment involves the use of vaccines, interleukin, and other drugs. These therapies can help to slow the growth of cancer in the bone.
Most clinically relevant cell lines for prostate cancer are readily available. However, there are still many questions about the mechanisms of extravasation, the survival of cancer cells in bone, and their interactions with the bone microenvironment.
Various animal models have been developed to study the pathogenesis of prostate cancer. These models need to closely mimic the process of prostate cancer in humans. These new models must be able to recapitulate the evolutionary changes in the tumor.
Most of the animal models used to study prostate cancer are not able to reproduce the natural progression of the disease. These models require further work to determine the reasons for the development of metastatic disease.
To understand the development of bone metastases in prostate cancer, a new in vivo model is needed. This model needs to be able to understand the properties of disseminated prostate cancer cells that preferentially colonize bone.
Other noncancerous conditions of the prostate
Besides prostate cancer, there are other noncancerous conditions of the prostate that can lead to urinary problems. These problems include inflammation, infections, and obstruction. If left untreated, these problems can cause problems in the lower urinary tract, such as backflow of urine and swelling of the bladder.
The prostate gland is a small walnut-shaped gland located in the lower portion of the pelvis. The prostate surrounds the urethra, which carries urine out of the bladder. As the prostate grows in size, it can squeeze the urethra and obstruct the flow of urine. If this happens, the kidneys may not be able to handle the pressure.
The prostate is also the site of a number of bacterial infections. These infections can lead to prostatitis. Prostatitis is not a risk factor for prostate cancer, but it can be a sign of a more serious problem. Treatment may involve antibacterial drugs and other supportive treatments.
Primary malignant lymphoma of the prostate accounts for 0.09% of all prostate tumors. It is rare, but symptoms can include fever, chills, and weight loss. This type of cancer may also lead to night sweats.
Other noncancerous conditions of the prostate that are not cancer include benign prostatic hyperplasia (BPH), chronic bacterial prostatitis, and granulomatous prostatitis. Some types of granulomatous prostatitis are idiopathic, and others are associated with systemic granulomatous diseases.
Approximately 50% of all men will develop prostatitis at some point in their lives. However, it does not increase the risk of other prostate diseases.
Health A to Z. (n.d.). HSE.ie. https://www2.hse.ie/az/
U.S. National Library of Medicine. (n.d.). https://www.ncbi.nlm.nih.gov/
Directory Health Topics. (n.d.). https://www.healthline.com/directory/topics
Health A-Z. (2022, April 26). Verywell Health. https://www.verywellhealth.com/health-a-z-4014770
Harvard Health. (2015, November 17). Health A to Z. https://www.health.harvard.edu/health-a-to-z
Health Conditions A-Z Sitemap. (n.d.). EverydayHealth.com. https://www.everydayhealth.com/conditions/