What Are Blood Cell Disorders?
Several kinds of Blood Cell Disorders can affect your body and the way it works. These include bleeding (platelet) disorders, leukopenias, hemophilia, Myelodysplastic syndromes, and primary thrombocythemia. If you have these disorders, you need to know what causes them so that you can take the right steps to get treatment.
Previously called myelodysplastic anemia, myelodysplastic syndromes are a group of bone marrow disorders. They are caused by the bone marrow not producing enough normal blood cells. These cells, which include red blood cells, white blood cells, and platelets, help fight infections and prevent bleeding. They are used to transport oxygen and are important for the body to function properly.
Myelodysplastic syndromes affect people of all ages but are more common in older adults. They can also occur in people who have exposure to certain chemicals, such as radiation therapy, chemotherapy, and benzene. The National Organization for Rare Disorders (NORD) offers information on myelodysplasia and other types of rare diseases.
The symptoms of myelodysplastic syndromes include low blood counts, fatigue, and bleeding. Some cases are life-threatening, but many can be controlled with treatment. Medications can help slow the progression of the disease and reduce the need for red blood cell transfusions. Some doctors also recommend regular exams, and some centers will test for genetic abnormalities.
Myelodysplastic syndromes are grouped into two categories: primary and secondary. Primary myelodysplastic syndromes occur because of a genetic disorder. Secondary myelodysplastic syndromes occur after treatment. Treatment for both types of myelodysplastic syndromes can include medications that suppress the immune system, growth factor therapy, and bone marrow transplant.
Symptoms of myelodysplastic syndromes may include bruising, fatigue, and weakness. The bone marrow usually produces too many immature blood cells. These cells spill out of the bone marrow into the bloodstream. These cells are usually harmless, but they may cause bleeding. A complete blood count with a differential can detect myelodysplastic syndromes.
People with myelodysplastic syndromes may be eligible for clinical trials. Treatment for these types of diseases is usually a bone marrow transplant. However, a transplant carries a high risk of serious complications.
Having leukopenias and blood cell disorders can be a symptom of several health problems. They can be caused by a number of factors, including medications, infections, cancer, and bone marrow disorders. It is important to identify and treat the underlying problem. This will help prevent complications from occurring.
The first step in diagnosing leukopenias and blood cell problems is to have a complete blood count (CBC). This test will measure the number of white blood cells, red blood cells, and platelets in the blood. The results will help the doctor determine the cause. The CBC is also used to determine whether or not a person has an infection.
If you have leukopenias and blood cell diseases, you will be at a higher risk of developing infections. This is because the body does not have enough white blood cells to fight off infections. It is important to get treatment to lower your risk of developing an infection. You can also prevent infections by staying up to date with recommended vaccinations and handwashing.
If you have leukopenias, you may have an enlarged spleen. This enlarged spleen can make it difficult for the body to produce white blood cells. Leukopenia can also occur if the body is not producing enough white blood cells to fight off infections. This can occur because of conditions such as cancer, anemia, or infection of the spleen.
Medications, especially those that suppress the immune system, can cause leukopenias. Some medications for cancer, like chemotherapy, cause leukopenia. Other drugs, such as corticosteroids, may also cause leukopenia.
If you have leukopenias, your doctor will try to get your white blood cell count up to normal. You may need medications to help increase your white blood cell count. You may also need a stem cell transplant to help replenish the body’s supply of white blood cells.
Thrombocythemia and blood cell disorders are a group of diseases that involve the production of abnormal blood cells in the bone marrow. These abnormal blood cells are called platelets. These blood cells are used to help clot blood and plug damaged blood vessels. If you have thrombocythemia, you may experience clotting problems, bleeding problems, and bruising.
The disease causes blood cells to become uncontrollable and produce too many of them. The bone marrow then produces more platelets than it needs. The excess platelets will crowd into blood vessels and form clots. This can result in strokes, heart attacks, and chest pain. Typically, people who have primary thrombocythemia have a higher risk of developing blood clots.
Primary thrombocythemia and blood cell disorders can affect adults and children. Primary thrombocythemia is a serious condition that requires immediate treatment. It is particularly dangerous for pregnant women.
Primary thrombocythemia is more common in women than in men. Symptoms include bruising, night sweats, and fever. People with essential thrombocythemia have an increased risk of strokes, heart attacks, and pregnancy complications.
Primary thrombocythemia can be diagnosed through blood tests. Doctors can also perform a bone marrow biopsy to evaluate the condition. This procedure is done by taking a sample of the bone marrow, typically from the pelvis or breastbone. This sample is then viewed under a microscope.
Doctors may also perform tests to detect a mutation in the JAK2 gene. This gene controls the production of blood cells. If the JAK2 gene is mutated, the production of blood cells may become uncontrolled. Eventually, uncontrollable cells will produce scar tissue in the bone marrow, which blocks the production of normal blood cells.
Treatments to reduce the number of blood cells produced can help prevent clotting. Some treatments are taken as prescription medications. Others may be taken over the counter.
Bleeding (platelet) disorders
Various medical conditions can cause bleeding disorders, including platelet dysfunction. Some of the conditions are inherited, while others are acquired. If you think you have one of these conditions, it’s important to seek medical help as soon as possible.
Platelets are tiny blood cells. They help stop bleeding by forming a clot. They are made in the bone marrow. They’re also responsible for carrying oxygen to different organs. Platelets are also used to seal wounds. They are grouped into two types, platelet aggregation, and platelet secretion.
Some medical conditions can cause platelet dysfunction, such as splenic failure. Some medications may also destroy platelets, such as anticonvulsants. Others can cause a low platelet count, such as quinine.
Certain diseases may also cause bleeding disorders. These include autoimmune disorders, which can cause immune thrombocytopenia. Platelets are also damaged by bacterial infections in the blood.
In addition, certain medications can cause bleeding, including sulfa-containing antibiotics and anticonvulsants. Bleeding can occur internally or externally. Symptoms include bruising, nosebleeds, petechiae, ecchymoses, and black-and-blue bruises. You may also feel cold or tired. If you experience bleeding, go to the emergency room immediately.
If you have a platelet disorder, you may be able to get treated. Your healthcare provider may prescribe medication to increase your platelet count. Some people also require hematopoietic cell transplantation to replace their platelet-making abilities.
The National Heart Foundation offers education about bleeding disorders. They also hold a conference every year, which allows people with bleeding disorders to connect with others. The conference also gives people with platelet disorders the opportunity to learn more about their condition and the treatment options available.
Bleeding disorders can be prevented by following the recommendations of your healthcare provider. Early detection and treatment can help improve your quality of life and decrease your risk of complications.
Approximately 1 percent of the United States population suffers from bleeding disorders. These disorders include hemophilia and von Willebrand disease. In most cases, bleeding disorders are passed from parents to children. However, they can also develop later in life.
People with hemophilia often have low levels of clotting factor in their blood. This can lead to an increase in bleeding. They are also more likely to be prone to blood-borne infections, such as hepatitis. People who are hemophiliacs should get regular blood tests, as well as get vaccinated against blood-borne viruses. They also need to maintain a healthy weight. If bleeding is a problem, they should get a clotting factor infusion.
The most common type of hemophilia is hemophilia A. This is caused by a mutation in the clotting factor gene. People with hemophilia A need to take daily clotting factors. They may also have to take anticoagulants, which help to prevent clots from breaking down.
Some hemophiliacs have to take immune-suppressing drugs to reduce their antibody levels. They may also need to increase the dosage of the recombinant factor. These are medications that allow the body to make clotting factors without factor VIII.
The National Hemophilia Foundation (NHF) is dedicated to finding better treatments for inheritable bleeding disorders. It offers educational materials and local chapters to help people affected by bleeding disorders. They also advocate for cures at all levels of government.
The Community Counts Registry for Bleeding Disorders is a federally funded project that provides free inhibitor testing. It also helps to collect data on bleeding disorders.
People with hemophilia should maintain a first aid kit. They should also write down all new treatment instructions, as well as questions they have about their condition. They should also know how to contact their doctor after office hours.
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