Angioedema – Symptoms, Causes, Treatment, Genetics, and More
Symptoms, Causes, Treatment, Genetics, and more are all covered in this article. If you are dealing with angioedema, it is important that you understand what causes this condition and how to treat it.
Symptoms
Symptoms of angioedema may include swelling, dizziness, and difficulty breathing. The condition can be life-threatening, so it’s important to get medical attention if symptoms occur.
Swelling can occur in the lips, chin, face, neck, and other parts of the body. Angioedema can be caused by many different things, including allergies, medications, food, and venom from certain insects. However, the majority of cases are caused by an allergic reaction.
The swelling may appear suddenly or gradually over a few hours. Swelling can be very painful, and it may be itchy. It may also feel tight. People with severe cases may need to take an adrenaline auto-injector while they wait for an ambulance.
If the swelling occurs in the throat, it can be life-threatening. People with angioedema can be treated at home. For more serious cases, people may need to be hospitalized.
Angioedema can also cause problems with the digestive system and other parts of the body. People with this condition can experience nausea, vomiting, and pain in the abdomen. In addition, the swelling can be painful, and the skin can become itchy and red. This condition is also known to cause weight gain.
When angioedema is caused by an allergy, people may have hives. Hives are small bumps or welts that appear on the skin. People with angioedema are more likely to have hives than people without the condition. Hives may appear in clusters, or they may appear alone. People with hives may also experience pruritus (itchiness).
In addition, people with angioedema may experience a high white blood cell count. This can lead to dangerously low blood pressure. People with this condition may have trouble breathing or may experience other symptoms such as dizziness, fever, stomach upset, or loss of appetite.
Causes
Depending on the cause, angioedema can be life-threatening. It can be caused by infections, medication, food allergies, and hereditary factors. It can also be a side effect of certain medical procedures.
Hereditary angioedema occurs when there is a deficiency of the complement pathway, a part of the immune system. It may also be a result of other factors such as damage to the immune system, a genetic disorder, or an autoimmune disorder. This condition can affect the blood vessels, lymphoid tissues, and connective tissues. It is more common in children than adults.
Allergies are a common cause of angioedema. This reaction occurs when the body releases a chemical called histamine, which causes fluid to leak from blood vessels. These reactions may involve the lungs or the mouth, making breathing difficult.
Drug-induced angioedema is a type of angioedema that is triggered by certain drugs. These include some medications used to treat heart failure, blood pressure, and certain other conditions. These include angiotensin-converting enzyme (ACE) inhibitors and bradykinin receptor, antagonists. These medications are often avoided in people who already have angioedema.
Food allergy reactions are often severe and can cause a drop in blood pressure. Depending on the type of allergy, the reactions may be limited to the lungs, mouth, or stomach. Usually, they are itchy hives that are raised and swollen. Medications can also trigger angioedema, but they usually don’t cause hives.
Symptoms of angioedema can range from mild swelling to serious, life-threatening problems. If the swelling affects the respiratory or GI tract, you may need intubation and/or other breathing support. A doctor can help you find out the cause of your swelling and work out preventive measures.
Genetics
Symptoms of hereditary angioedema can be life-threatening and recurrent. The most common areas of the body affected by this disorder are the eyes, hands, and digestive tract mucous membranes. In addition, dental procedures and injuries can also trigger symptoms.
Angioedema is a disorder characterized by the accumulation of excessive body fluid, usually due to injury or severe pain. It can also be caused by stress. Hereditary angioedema is a rare genetic disorder. It is caused by a deficiency of the C1-Inhibitor protein. The C1-Inhibitor is a member of the serpin protein superfamily. This group includes antithrombin III, heparin cofactor II, and a1-antitrypsin.
Genetic analysis is important in the diagnosis of hereditary angioedema. For a diagnosis, blood samples were collected from patients with symptoms and from healthy blood donors without angioedema. The samples were analyzed for the levels of complement proteins, complement enzymes, and the complement profile.
A mutation in the SERPING1 gene is one of the most common causes of hereditary angioedema. This mutation results in a functionally abnormal C1-INH protein. It also results in a loss of regulation of factor XIIa. This leads to excess production of bradykinin, which dilates the blood vessels.
Another mutation in the ANGPT1 gene, which is located on chromosome 8q23, causes a hereditary angioedema-like phenotype. These mutations also disturb the cytoskeletal assembly of vascular endothelial cells.
The F12 (factor XII) gene is also associated with angioedema. However, this mutation has not been reported in Asians.
Genetic testing is also indicated in cases of episodic angioedema, which has uncertain etiology. For example, if the symptoms of angioedema recur after a particular surgical procedure, genetic analysis is useful. The presence of de novo mutations in HAE is estimated to be 20 percent.
Treatment
Generally, treatment of angioedema requires medications taken orally. Antihistamines and steroid medications are used to reduce inflammation. For severe angioedema, these medications should be taken daily. If the swelling continues, a trip to the emergency room may be necessary.
In severe cases, a penlike device may be used to administer epinephrine, a type of adrenaline. In children, a dose of 0.01 mg/kg is administered. The dose is repeated every 5 to 15 minutes.
A review of medications may reveal angiotensin-converting enzyme (ACE) inhibitors. This drug can relax blood vessels and lower blood pressure. These drugs are often used to treat heart failure. However, they can also cause angioedema.
There are also cases of angioedema caused by an allergic reaction. In this condition, an allergy causes the release of histamine within the skin. In most cases, angioedema occurs in response to an insect bite, natural rubber latex, or a food allergy.
In addition to medications, lifestyle changes can help prevent angioedema. Avoiding known triggers is recommended. Try to avoid foods, drinks, and materials that may trigger a reaction. Also, be sure to carry an EpiPen with you at all times.
Antihistamines are a popular form of treatment for angioedema. Antihistamines are available over the counter and they work by blocking the effect of histamine on the body. Antihistamines usually work for one to two hours.
Corticosteroids are also used to treat angioedema. Corticosteroids can reduce the inflammation and itching associated with angioedema. Using ice packs can also reduce swelling.
Other treatments include using angiotensin-converting enzyme inhibitors (ACEIs), a class of drugs that relax blood vessels and lower blood pressure. These medications are commonly prescribed in the United States. However, they are sometimes avoided by people with an angioedema history.
Non-histaminergic angioedema
Angioedema is a clinical syndrome that involves swelling of one or more parts of the body, such as the mouth, throat, face, or lips. The swelling occurs when fluid leaks from a blood vessel into the surrounding tissue. It can be idiopathic or may be a side-effect of a medical procedure. The symptoms can be severe.
Angioedema is classified into histaminergic and non-histaminergic forms. Histaminergic angioedema responds to antihistamines for acute treatment. Antihistamines can be used alone or in combination with steroids. In addition, corticosteroids can be used to suppress inflammatory mediators. In addition, H-2 blockers can be added to reduce histamine effects.
The treatment of acute episodes is dependent upon their location. The initial management should focus on the airway. If the patient is having trouble breathing, he should be given epinephrine. If he is hypotensive, he should be given intravenous diphenhydramine. If there is an underlying airway obstruction, he should be given epinephrine, steroids, and IV fluids.
The study focuses on the pathophysiology and treatment of histamine- and bradykinin-induced angioedema. In addition to the clinical data, the patient’s medical charts and laboratory investigations were obtained.
Patients included in the study were 7 years of age or older. They had recurrent attacks of angioedema in their extremities, which were typically precipitated by trauma. In addition, the patients had to be free from other known causes of angioedema. They had to have normal muscle enzymes, tryptase, and a C1 inhibitor.
The patients were given a course of omalizumab every 4 weeks for 6 months. This proved to be an effective treatment for recurrent attacks of angioedema. In addition, it showed a rapid response.
In idiopathic non-histaminergic angioedema, there may be no urticaria. This condition may be triggered by a variety of causes, including nephropathy. It may also be triggered by allergic reactions. Idiopathic non-histaminergic angioedema may be treated with rituximab.
Health Sources:
Health A to Z. (n.d.). HSE.ie. https://www2.hse.ie/az/
U.S. National Library of Medicine. (n.d.). https://www.ncbi.nlm.nih.gov/
Directory Health Topics. (n.d.). https://www.healthline.com/directory/topics
Health A-Z. (2022, April 26). Verywell Health. https://www.verywellhealth.com/health-a-z-4014770
Harvard Health. (2015, November 17). Health A to Z. https://www.health.harvard.edu/health-a-to-z
Health Conditions A-Z Sitemap. (n.d.). EverydayHealth.com. https://www.everydayhealth.com/conditions/
